Clinical relevance of recipient leukocyte infusion (RLI) therapy

Invariant NKT cells are required for antitumor responses induced by host-versus-graft responses.

Based on clinical observations, we have previously shown in a murine model that recipient leukocyte infusion (RLI) induces a host-versus-graft reaction in mixed bone marrow chimeras and that rejection of donor cells leads to a specific antitumor response against recipient malignancies. This response is dependent on T cells and IFN-gamma. We investigated the role of NKT cells (NKTs) in this phen...

Leukocyte CD11/CD18 integrins: biological and clinical relevance.

The integrin family consists of a series of related alpha beta heterodimers (subunits of 95,000-200,000 Mw) involved in a variety of cell-matrix and cell-cell adhesion functions. Leukocyte adhesion has biological importance in numerous processes involving host defense. The CD11/CD18 integrins are differentiated antigens which play a critical role in this mechanism. CD11a/CD18 are apparent on ea...

Clinical Relevance of Immunoresistance to Botulinum Therapy

Because botulinum toxin is a bacterial antigen, the therapy with this biological bears the risk that the formation of antibodies is elicited which can neutralize the neurotoxin. Several factors have an impact on this immune response. There are (unknown) patientrelated factors but also the dose, the injection interval and the purity of the product play a role in the formation of antibodies. Seve...

Mechanisms of the Antitumor Responses and Host-versus-Graft Reactions Induced by Recipient Leukocyte Infusions in Mixed Chimeras Prepared with Nonmyeloablative Conditioning: A Critical Role for Recipient CD4 T Cells and Recipient Leukocyte Infusion-Derived IFN- -Producing CD8 T Cells

The clinical relevance of response variability to antiplatelet therapy.

Interindividual variability in the pharmacological response to antiplatelet drugs has been reported in some studies. Suboptimal response to aspirin, as determined by specific tests (serum thromboxane B(2)), appears to be rare and in most cases is caused by poor compliance. In contrast, studies using specific tests to measure the pharmacological effect of clopidogrel showed a wide variability of...